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Design and analyze mathematical algorithms of intestinal
absorption and metabolism of multicomponent drug
DONG Ling， XIANG Jia-mei， WANG Yun*， WU Rui-guang， TANG Ming-min， SUN Mo-han
（Beijing University of Chinese Medicine， Beijing 100102， China）
[Abstract] Evaluation of the permeability mainly focuses on intestinal absorption in biopharmaceutics xlassification aystem （BCS）. It is more complicated that the absorption and metabolism under multicomponent environment in biopharmaceutics classification system of Chinese materia medica （CMMBCS） compared with single component environment， which needs suitable mathematical models to be described. Therefore， with full consideration of existing single component mathematical algorithm combining with the characteristics of intestinal absorption and metabolism， we explored and designed a new mathematical algorithm of intestinal absorption and metabolism of multicomponent drug. Then we put forward a new coefficient，Pinfluence， the relative change rate of the single component′s intestinal absorption and metabolism under multicomponent environment compared with single component environment， which described the influences of intestinal absorption and metabolism of the component under multicomponent environment. Moreover，Pinfluence highlights the distinctive characteristics of multicomponent drug′s intestinal absorption and metabolism， and lays the foundation for the construction of CMMBCS.
[Key words] biopharmaceutics classification system of Chinese materia medica； multicomponent drug； mathematical algorithms； intestinal absorption and metabolism； permeability coefficient
doi：10.4268/cjcmm20142302
[責任編輯 張寧寧]