本文結果表明，DN患者存在血清HGF，TGF-β1，CysC水平的紊亂，表現為高TGF-β1，CysC和低HGF，與健康組比（P3
（1.Department of Endocrinology， The People′s Hospital of Jinhua， Jinhua 321000， China；
2. Department of Medicine， Jinhua Polytechnic Medical College， Jinhua 321017， China；
3.Department of Traditional Chinese Medicine， Jinhua Polytechnic Medical College， Jinhua 321017， China）
[Abstract] Study the serum level of HGF，Cys C and TGF-β1 in type 2 diabetic nephropathy （DN）， the infect of Pingshen decoction on those index. Selected 69 cases of 2 type DN and randomly devided into therapy group （36cases） and control group （33 cases）.The therapy group were treated with Pingshen decoction 1 dose/d， bid po.The control group were treated with NephritisShu tablet， 6 tablet， tid po. 8 weeks was a course. Before and afeter treatment，we examine the serum level of HGF，Cys C and TGF-β1 by ELISA and immunonephelometry， and compare with 30 cases of healthy control group. The study demonstrates that before treatment， the serum level of HGF in both groups were significantly lower than healthy control group （P
[Key words] diabetic nephropathy（DN）； early stage； hepatocyte growth factor； cystatin C； transforming growth factor-β1（TGF-β1）； Chinese herb medicine
doi：10.4268/cjcmm20140635