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Study on pharmacokinetics of geniposide in mice administrated by Xingnaojing
microemulsion and mPEG2000-PLA modified Xingnaojing microemulsion
WEN Ran CHEN Xiao-lan LI Hui-yun GUO Qing-li LU Yang DU Shou-ying1*
（1.School of Chinese Pharmacy， Beijing University of Chinese Medicine， Beijing 100102， China；
2. Department of Materia Medica， Guiyang Institute of Traditional Chinese Medicine， Guiyang 550002， China）
[Abstract] An HPLC method for the determination of geniposide concentration in mouse plasma was developed and the pharmacokinetics after intranasal administration of Xingnaojing microemulsion （XNJ-M） and mPEG2000-PLA modified Xingnaojing microemulsion （XNJ-MM） were investigated. Eighty mice were treated by XNJ-M and XNJ-MM nasally. The plasma samples were collected at different times and the drug in samples was detected by HPLC. The pharmacokinetic parameters were calculated by the software of Kinetica. The pharmacokinetic parameters of geniposideof XNJ-M were Cmax（4.36±2.69） mg·L-1， tmax1 min， MRT（29.73±4.54）min， AUC（53.63±14.03） mg·L-1·min. The pharmacokinetic parameters of geniposide of XNJ-MM were Cmax（9.75±4.14） mg·L-1， tmax1 min， MRT（22.34±2.90） min， AUC（131.87±40.13） mg·L-1·min. Geniposide can be absorbed into bloodin a higher degree after intranasal administration with XNJ-MM compared to XNJ-M， which maybe caused by its less irritating and more absorption.
[Key words] Xingnaojing microemulsion； mPEG2000-PLA； geniposide； intranasal administration； pharmacokinetics
doi：10.4268/cjcmm20140631