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Determination of lignans in Schisandrae Sphenantherae
Fructus from different regions
YANG Jie1，2， DUAN Jin-ao 1，2， LI Guo-long1， ZHU Zhen-hua1， ZHU Tai-lei1 ， QIAN Da-wei1，2， TANG Zhi-shu1*
（1.Shaanxi University of Chinese Traditional medicine Collaborative Innovation Center of Chinese Medicinal Resources
Industrialization/Shaanxi Key Laboratory of Chinese Pharmaceuticals and Drug Innovation Xianyang 712046， China；
2. Nanjing University of Chinese Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources
Industrialization， and National and Local Collaborative Engineering Center of Chinese Medicinal Resources
Industrialization and Formulae Innovative Medicine， Nanjing University of Chinese Medicine， Nanjing 210023， China）
[Abstract] With an objective to provide an experimental basis for scientific officinal of Schisandrae Sphenantherae Fructus， this research uses UPLC-TQ/MS method to analyze 7 different kinds of lignan in 70 batches of Schisandra sphenantherae Fructus samples from 9 regions.The results showed that in the area south of Qinling mountains， Schisandrae sphenantherae Fructus from Zhashui county and Shanyang county of Shangluo mainly contained schisantherin A and deoxyschizandrin.However， Schisandrae sphenantherae Fructus from Mei county of Baoji， Shiquan county and Ningshan county of Ankang， and Lueyang county of Hanzhong， mainly contained anwuligan. Samples from Ningshan county also consists relatively high level of deoxyschizandrin.In the central area of Qinling mountains and the Daba mountains， Schisandrae Sphenantherae Fructus from Nanzheng county of Hanzhong mainly contained schisanhenol and deoxyschizandrin.In conclusion， the kinds and level of lignan differ significantly in Schisandrae sphenantherae Fructus produced in different regions. In practical application， Schisandrae Sphenantherae Fructus produced in different regions should be distinguished and differently applied based on their main effective components corresponding to different diseases， which can lead to the best clinical use.
[Key words] Schisandrae Sphenantherae Fructus； lignin； LC-MS
doi：10.4268/cjcmm20142332
[責任編輯 丁廣治]