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Study of attribution of multicomponent original medicinal materials in
Gegen Qinlian decoction with intestinal permeability
ZHU Mei-ling， YANG Wen-ning， DONG Ling*， DONG Hong-huan， HOU Cheng-bo， LIU Yang*
（Beijing University of Chinese Medicine， Beijing 100102， China）
[Abstract] The complex level of constructing biopharmaceutics classification system of Chinese materia medica（CMMBCS） was the study of traditional Chinese compound， on the premise of insisting that the multicomponent simultaneous determination， when carrying out the study of intestinal permeability， the primary task was to define the source of the components that was absorbed through the intestinal wall， namely， which medicinal material the components belonged to in traditional Chinese compound. The technology of chemical fingerprint and in vitro everted gut sac model were used in this research to make multicomponent an intuitive source attribution which permeated the intestine in the classic formula Gegen Qinlian decoction， and to lay the foundation for the further qualitative and quantitative research of intestinal permeability.
[Key words] biopharmaceutics classification system of Chinese materia medica； Gegen Qinlian decoction； permeability； in vitro everted gut sac； multicomponent； chemical fingerprint
doi：10.4268/cjcmm20142303
[責任編輯 張寧寧]