加味溫膽湯對實驗性冠心病痰濁血瘀證家兔模型血清IL—6水平的影響
作者：張麗麗 李雁
[摘要] 目的 通過觀察加味溫膽湯對冠心病痰濁血瘀證動物模型血清IL—6水平的影響，以探討其在冠心病發病中的作用機製。 方法 采用冠狀動脈結紮術和高脂飼料喂養法，建立近似冠心病痰濁血瘀證動物模型，將家兔40隻隨機分成5組，每組8隻，即空白組、模型組、中藥低劑量組、中藥中劑量組、中藥高劑量組，中藥低、中、高劑量組分別以加味溫膽湯治療14 d，采用ELISA法觀察加味溫膽湯對冠心病痰濁血瘀證動物血清IL—6水平的影響。 結果 中藥高、中、低劑量組，與模型組相比，可改善家兔血液流變學變化，抑製血清IL—6水平。 結論 加味溫膽湯能夠改善家兔血液流變學變化，抑製血清IL—6水平，能夠穩定冠狀動脈粥樣硬化斑塊，對冠心病痰濁血瘀證起到一定的防治作用。
[關鍵詞] 加味溫膽湯；冠心病痰濁血瘀證；IL—6
[中圖分類號] R541.4 [文獻標識碼] A [文章編號] 1673—9701（2012）24—0001—02
Effect of Wendan Decoction on serum IL—6 level of experimental coronary heart disease phlegm and blood stasis syndrome model in rabbits
ZHANG Lili LI Yan
Cardiovascular Division，Heilongjiang Academy of TCM，Haerbin 150036，China
[Abstract] Objective To observe Wendan Decoction infulence on serum IL—6 level of the coronary heart disease phlegm and blood stasis syndrome model in rabbits and to investigate its mechanism for coronary heart disease. Methods Replicated the animal models with the method of coronary artery ligation and high fat feeding. 40 rabbits were devided into 5 groups at random， the blank group and the other four groups with 8 rabbits each. Treat the rats of high dose traditional Chinese medicine group and low dose traditional Chinese medicine group with the treatment of Wendan Decoction about 14 days. At the same time， elise method was used to to observe the effect on the coronary heart disease Phlegm and blood stasis Syndrome Model in rabbits serum IL—6 level. Results The high dose traditional Chinese medicine group and low dose traditional Chinese medicine group comparison with model group，prescription of Wendan Decoction can improve the blood rheology of the rabbits model with coronary heart disease. It also can inhibit serum the level of serum IL—6. Conclusion The prescription of Wendan Decoction can improve the blood rheology of the rabbits model with coronary heart disease and inhibit serum the level of serum IL—6. To stabilize the coronary atherosclerotic plaque. Phlegm Blood Stasis Syndrome of coronary heart disease plays a role in prevention and treatment.