42.It is no evil for things to undergo change， and no good for things to subsist in consequence of change.
43.Time is like a river made up of the events which happen， and a violent stream； for as soon as a thing has been seen， it is carried away， and another comes in its place， and this will be carried away too.
44.Everything which happens is as familiar and well known as the rose in spring and the fruit in summer； for such is disease， and death， and calumny， and treachery， and whatever else delights fools or vexes them.
45.In the series of things those which follow are always aptly fitted to those which have gone before； for this series is not like a mere enumeration of disjointed things， which has only a necessary sequence， but it is a rational connection： and as all existing things are arranged together harmoniously， so the things which come into existence exhibit no mere succession， but a certain wonderful relationship.
46.Always remember the saying of Heraclitus， that the death of earth is to become water， and the death of water is to become air， and the death of air is to become fire， and reversely. And think too of him who forgets whither the way leads， and that men quarrel with that with which they are most constantly in communion， the reason which governs the universe； and the things which daily meet with seem to them strange： and consider that we ought not to act and speak as if we were asleep， for even in sleep we seem to act and speak； and that we ought not， like children who learn from their parents， simply to act and speak as we have been taught.
47.If any god told thee that thou shalt die to-morrow， or certainly on the day after to-morrow， thou wouldst not care much whether it was on the third day or on the morrow， unless thou wast in the highest degree mean-spirited- for how small is the difference？- So think it no great thing to die after as many years as thou canst name rather than to-morrow.