2型糖尿病患者C反應蛋白和瘦素表達水平檢測與胰島素抵抗的相關性
論著
作者:艾雅琴
[摘要] 目的 探討2型糖尿病患者C反應蛋白和瘦素表達水平與胰島素抵抗的相關性。 方法 選取2010年3月~2012年7月在我院內分泌科就診的2型糖尿病患者166例作為觀察組,並按照肥胖程度分為T2DM組(80例)和T2DM合並肥胖組(86例),同時選取同期體檢健康者45例為對照組。檢測空腹血糖(FPG)、空腹胰島素(FINs)、C反應蛋白(CRP)、瘦素(leptin)並計算胰島素抵抗指數,利用Pearson相關性分析探討糖尿病患者胰島素抵抗的相關原因。 結果 觀察組FPG、FINs、CRP、Leptin、HOMA-IR均顯著高於對照組(t=8.642、10.720、5.961、6.325、5.467,P
[關鍵詞] 2型糖尿病;C反應蛋白;瘦素;胰島素抵抗
[中圖分類號] R587.1 [文獻標識碼] A [文章編號] 1673-9701(2015)29-0001-03
The correlated analysis among C reactive protein, leptin expression and insulin resistance level in patients with type 2 diabetes
AI Yaqin
Department of Endocrinology, the Fourth Affiliated Hospital of Nanchang University, Jiangxi 330003, China
[Abstract] Objective To explore the correlation among the C-reactive protein, leptin levels and insulin resistance of patients with type 2 diabetes. Methods 166 cases with type 2 diabetic were taken as observation group which were grouped into T2DM group(n=80) and T2DM with obesity group(n=86) according to the degree of obesity from March 2010 to July 2012. Meanwhile, 45 healthy cases were selected in the same period as the control group. The correlation between the expression of C-reactive protein, leptin levels and insulin resistance of patients with type 2 diabetes were investigated by determining the fasting blood glucose(FPG), fasting insulin (FINs), C-reactive protein (CRP), leptin, and insulin resistance index. Results The FPG, FINs, CRP, leqtin, and HOMA-IR in observation group were significantly higher than those in control group(t=8.642, 10.720, 5.961, 6.325, 5.467, P
[Key words] Type 2 diabetes; C-reactive protein; Leptin; Insulin resistancec
隨著現代社會發展的節奏加快,以及人口老齡化的加劇,糖尿病(diabetes mellitus,DM)的發病率也逐年上升[1,2]。胰島素抵抗是糖尿病的主要原因[3]。近年來多項研究結果表明,瘦素(Leptin)、C反應蛋白(CRP)等與2型糖尿病患者的胰島素抵抗密切相關[4-6]。本研究選取2010年3月~2012年7月在我院內分泌科就診的2型糖尿病患者166例,按照肥胖程度進行分組,同時選取同期體檢健康者45例為對照組,通過檢測患者相關生化指標,了解患者C反應蛋白、瘦素表達水平以及胰島素抵抗狀況,並探討C反應蛋白和瘦素表達水平與胰島素抵抗的相關性,現報道如下。